منابع مشابه
[Dexmedetomidine: pharmacology and clinical application.].
BACKGROUND AND OBJECTIVES Dexmedetomidine is the newest alpha2-adrenergic agonist for clinical application. It has a fast onset, is metabolized by the liver and mostly excreted by the urine. This review aimed at presenting pharmacokinetic and pharmacodynamic profiles of dexmedetomidine and its clinical applications. CONTENTS Dexmedetomidine pharmacokinetic and pharmacodynamic profiles are pre...
متن کاملClinical application, the use of dexmedetomidine in intensive care sedation
Optimal sedation strategy in the critically ill should achieve effective analgesia, targeted sedation and reduced risk of delirium and agitation. Whilst there is no single agent that can achieve these goals for all patients, a multimodal approach may optimise the use of different agents through multiple modes of action and reduce possible adverse events. This practice review provides an evidenc...
متن کاملEffect of Dexmedetomidine on Postoperative Pain in Knee Arthroscopic Surgery; a Randomized Controlled Clinical Trial
knee surgery. The purpose of this study was to assess the analgesic effects of intra-articular injection of a dexmedetomidine following knee arthroscopy. Methods: Forty six patients schadualed for arthroscopic knee surgery under general anaesthesia, were randomly devided into two groups. Intervention group received 1μg/kg dexmedetomidine (D) and isotonic saline. Control group received 25ml is...
متن کاملClinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine
Dexmedetomidine is an α2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function. It is potent and highly selective for α2-receptors with an α2:α1 ratio of 1620:1. Hemodynamic effects, which include transient hypertension, bradycardia, and hypotension, result from the drug's peripheral vasoconstrictive and symp...
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ژورنال
عنوان ژورنال: Southern African Journal of Anaesthesia and Analgesia
سال: 2010
ISSN: 2220-1181,2220-1173
DOI: 10.1080/22201173.2010.10872681